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Norco is a brand name for a combination medication containing two active ingredients: hydrocodone and acetaminophen. Hydrocodone is an opioid pain reliever, and acetaminophen is a non-opioid pain reliever and fever reducer. Here's an overview of Norco, its uses, potential side effects, and precautions. Norco contains hydrocodone, which is an opioid, and as such, it carries a risk of more severe side effects such as respiratory depression, dependence, and addiction. Misuse or overuse can lead to serious health issues.